Bioactive Small Molecules
Medchemexpress LLC (S)-(-)-Bay-K-8644 | 98625-26-4 | C16H15F3N2O4 | 1 MG
(S)-(-)-Bay-K-8644 is an agonist of the L-type Ca2+ channel, activating Ba2+ currents (IBa) with an EC50 of 32 nM. This specific isomer acts as an agonist, differentiating it from the antagonist effects of its R(+) counterpart. It can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in guinea pig antrum gastric myocytes and enhances Ca2+ channel activity at concentrations of 3-30 μM. It also inhibits contractile responses in rat tail artery strips and increases whole-cell Ca2+ currents in A7r5 smooth muscle cells.
- Acts as an agonist of L-type Ca2+ channel.
- Activates Ba2+ currents with an EC50 of 32 nM.
- Prevents inhibitory actions of cyclic nucleotide pathways on IBa.
- Enhances Ca2+ channel activity at 3-30 μM.
- Inhibits contractile responses caused by FPL 64176.
- Increases whole-cell Ca2+ currents in A7r5 smooth muscle cells.
Medchemexpress LLC BMS-37 | 1675202-20-6 | C27H32N2O4 | 50 MG
BMS-37 is a potent PD-1/PD-L1 immune checkpoint inhibitor, demonstrating an IC50 towards the PD-L1/PD-L1 complex within the range of 18 to 200 nM. This compound is valuable for research into PD-L1-induced T-cell exhaustion or as a PD-L1 ligand for the synthesis of PROTAC molecules.
- Inhibits PD-1/PD-L1 immune checkpoint
- IC50 towards PD-L1/PD-1 complex between 18 to 200 nM
- Useful for studying PD-L1-induced T-cell exhaustion
- Can serve as a PD-L1 ligand for PROTAC molecule synthesis
Cayman Chemical 7-APDB (hydrochloride), Purity: ≥98%, 5 mg
An analytical reference standard categorized as a benzofuran; intended for research and forensic applications
Medchemexpress LLC 8-phenyl-BODIPY 505/515 | 194235-40-0 | 324.18 g/mol | C19H19BF2N2 | 10 MG
8-Phenyl-BODIPY 505/515 is a phenyl-substituted BODIPY derivative fluorophore used as a fluorescent probe. It exhibits excitation around 502 nm and emission around 515 nm, and is supplied in small research quantities for labeling and imaging applications.
- phenyl-substituted BODIPY fluorophore
- excitation ~502 nm, emission ~515 nm
- molecular weight 324.18 g/mol
- chemical formula C19H19BF2N2
- available in small vial sizes for research use
Cayman Chemical NVP-AAM077, Purity: ≥95% (mixture of isomers), CAS: 2514919-70-9, 10 mg
An NMDA receptor antagonist (IC50 = 0.008 µM); selective for NMDA receptors containing NR1A/NR2A subunits over NMDA receptors containing NR1A/NR2B subunits (IC50s = 0.27 and 29.6 µM, respectively); inhibits MES-induced seizures in mice (ED50 = 23 mg/kg); inhibits NPC proliferation in the SVZ and SGZ at 10 mg/kg; impairs spatial memory in the Morris water maze in mice
Medchemexpress LLC FAM-DEALA-Hyp-YIPD | 99.4% | 1477.48 | 5 MG
FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1α peptide with a Kd of 180-560 nM.
- Assesses VHL binding in Fluorescence Polarization (FP) displacement assays.
- Evaluates the impact of VHL binding on degradation activity.
Medchemexpress LLC HY-N6962 1mg Medchemexpress, α-Spinasterol CAS:481-18-5 Purity:>98%
Medchemexpress, HY-N6962 1mg α-Spinasterol CAS:481-18-5 α-Spinasterol, isolated from Spinacia oleracea, has antibacterial activity. α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Autocamtide 2, amide | 98.6% | 1526.78 | 5 MG
Autocamtide 2, amide is a peptide substrate (100 μM final concentration) for CaMK family assays, intended for research use only.
- Substrate for CaMK family assays
- Solid appearance, white to off-white color
- Soluble in water at 50 mg/mL, requiring ultrasonic for dissolution
- Store powder at -80°C for 2 years or -20°C for 1 year
- Store in solvent at -80°C for 6 months or -20°C for 1 month
- Recommended storage is sealed and away from moisture
Medchemexpress LLC GNE 2861 | 1394121-05-1 | 98.97% | 406.48 | 100 MG
GNE 2861 is a PAK inhibitor that exhibits group II selectivity. It inhibits PAK4, PAK5, and PAK6 with IC50 values of 7.5 nM, 36 nM, and 126 nM, respectively.
- PAK inhibitor
- Exhibits group II selectivity
- Inhibits PAK4 with an IC50 of 7.5 nM
- Inhibits PAK5 with an IC50 of 36 nM
- Inhibits PAK6 with an IC50 of 126 nM
Medchemexpress LLC Mca-SEVNLDAEFK(Dnp)-NH2 | 1802078-32-5 | 98.8% | 1532.52 | 1 MG
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1.
- Peptide and derivatives
- Inhibitors and substrates
- Enzyme substrates
- Fluorescent dye
- Fluorescent substrate for peptidases
- Measures activity of BACE-1
- Inhibitor
Medchemexpress LLC Grpp (human) | 1132745-52-8 | 98.9% | 3384.47 | 500 UG
GRPP (human) is a 30 amino acid Gcg-derived peptide that causes slight increases in plasma insulin and decreases in plasma glucagon. It does not affect insulin secretion in rat islets.
- 30 amino acid Gcg-derived peptide
- Causes slight increases in plasma insulin
- Decreases plasma glucagon
- Does not affect insulin secretion in rat islets
- Requires sealed storage, away from moisture
- Powder stable for 2 years at -80°C
- Powder stable for 1 year at -20°C
- In solvent stable for 6 months at -80°C
- In solvent stable for 1 month at -20°C
Medchemexpress LLC PA22-2 (IKVAV sequence; laminin A-chain fragment) | 131435-36-4 | 98.96% | 2016.33 | 10 MG
PA22-2 (IKVAV sequence; Laminin A-chain fragment) is a biological active peptide. This peptide is derived from mouse laminin a1. Cell matrix substrate constituted with this peptide can promote neurite outgrowth.
- It is a biological active peptide.
- It is derived from mouse laminin a1.
- Cell matrix substrate constituted with this peptide can promote neurite outgrowth.
Cayman Chemical ML-396, Purity: ≥98%, CAS: 1630936-95-6, 10 mg
A positive allosteric modulator of group III mGluRs (EC50s = 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays); potentiates LSP4-2022-induced reductions in fEPSP slopes in mouse hippocampal slices; restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome at 30 mg/kg
Medchemexpress LLC Ssk36 (TFA) | 99.3% | 1771.04 (free base) | 25 MG
ssK36 TFA is a supersubstrate peptide designed for the histone methyltransferase (SET) domain protein 2 (SETD2). It adds methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. This peptide can be methylated by SETD2 over 100 times faster than the natural substrate H3K36, making it valuable for studying the catalytic mechanism of PKMTs, particularly substrate specificity and catalytic efficiency.
- Designed for the SETD2 protein, a specific PKMT.
- Adds methyl groups to H3K36 to form H3K36me3.
- Methylated over 100 times faster than the natural substrate H3K36.
- Used to study the catalytic mechanism of protein lysine methyltransferases (PKMTs).
- Suitable for investigating substrate specificity and catalytic efficiency.
eMolecules 293754-55-9 | T0901317 | Target Molecule | MFCD03412028 | 481.330 | C17H12F9NO3S | 0.000 | OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F | 200mg | 348530960
T0901317 | Target Molecule | 293754-55-9 | MFCD03412028 | 481.330 | C17H12F9NO3S | 0.000 | OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F | 200mg | 348530960