Bioactive Small Molecules
Apexbio Technology LLC Cyclopamine, 10mg. Cas: 4449-51-8 MFCD: MFCD09878269. Hedgehog (Hh) signaling Inhibitor
Cyclopamine is a naturally occurring Hedgehog (Hh)?specific small?molecule signaling steroidal alkaloid inhibitor, causes a profound inhibition of tumor growth, has significant anti?invasive, anti?proliferative and anti?estrogenic potency in human breast cancer cells [2] [1]. Other sizes are available. Please inqury us for quote.
Selleck Chemical LLC Rabdosia Rubescens Extract E3165-5MG
Rabdosiae Rubescentis Herba Extract is drawed from the dried aerial part of genus Rabdosia rubescens (Hemsl ) Hara of the Lamiaceae family which possesses several biological activities such as anti-bacteria anti-parasites anti-inflammation and anticancer
eMolecules 2464-18-8 | Medchem Express | Allocholic acid | 10mg | 532149178 | HY-125934 | MFCD28359001 | 408.579 | C24H40O5
AstaTech | 1-PYRIDIN-3-YL-ETHANONE OXIME | 5g | 449752855 | AB7740 | 95.000 | 5973-83-1 | MFCD00179685 | 136.154 | C7H8N2O
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Cayman Chemical ANTIBODY GSK256066 25mg
A potent PDE4 inhibitor (IC50s = 4.9, 3.2, 3.8, and 1.1 pM for PDE4A, PDE4B, PDE4C, and PDE4D, respectively); >380,000-fold selective for PDE4 over PDE1-3, -5, and -6 and >2,500-fold selective over PDE7; inhibits LPS-induced TNF-α production in human peripheral blood monocytes (IC50 = 0.01 nM) and human whole blood (IC50 = 126 pM); intratracheal adminstration inhibits LPS-induced pulmonary neutrophilia in rats (ED50 = 1.1 UG/kg); inhibits ovalbumin-induced pulmonary eosinophilia in rats (ED50 = 0.4 UG/kg) and LPS-induced pulmonary neutrophilia in ferrets (ED50 = 18 UG/kg)
Medchemexpress LLC Activated T Subunit | 956139-30-3 | C31H34ClN4O5P | 50 MG
Activated T Subunit is utilized in the synthesis of exon jumping oligomer conjugates. These conjugates complement specific target sites in the human anti-muscular atrophy protein gene, inducing exon 51 jumping. It is suitable for research related to muscular dystrophy, with a molecular weight of 609.05 and a purity of 99.64%. This product appears as a white to off-white solid.
- Utilized in the synthesis of exon jumping oligomer conjugates
- Induces exon 51 jumping
- Suitable for research related to muscular dystrophy
- Molecular weight of 609.05
- Purity of 99.64%
- White to off-white solid appearance
- For research use only
Apexbio Technology LLC GDC-0032, 10mg. Cas: 1282512-48-4 MFCD: MFCD26142641. PI3Kα inhibitor
GDC-0032 is a novel and potent benzoxepin inhibitor of PI3K isoform with the Ki value of 0.29nM for PI3K[1].GDC-0032 has been reported to potently inhibit PI3K and have the selectivity over other PI3Ks. Other sizes are available. Please inqury us for quote.
![Medchemexpress LLC D-phenylalanine, 3-bromo-N-[(1,1-dimethylethoxy)carbonyl]- | 261360-77-4 | MFCD01317704 | 10g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000266401.png-250.jpg)
Medchemexpress LLC D-phenylalanine, 3-bromo-N-[(1,1-dimethylethoxy)carbonyl]- | 261360-77-4 | MFCD01317704 | 10g
(R)-3-(3-Bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid is a phenylalanine derivative[1]
Medchemexpress LLC Eupatorin | 855-96-9 | 1 ML
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. It downregulates key inflammatory mediators, induces apoptosis and cell cycle arrest, and shows cytotoxic effects against various cancer cell lines. This compound also modulates receptor activities and specific cellular pathways, making it valuable for related research.
- Orally active flavonoid
- Antiproliferative and vasodilatory properties
- Downregulates NF-κB, MMP9, IL-1β, and TNF-α expression
- Induces apoptosis, G2/M phase cell cycle arrest, and ROS production
- Exhibits cytotoxic effects on a range of cancer cell lines
- Useful in research related to breast cancer, hypertension, and leukemia
Abcam Methyl 3-hydro x ydodecanoate, 3-Hydro x y fatty acid methyl ester, 25MG
MW 230.34 Da, Purity >98%. 3-Hydroxy fatty acid methyl ester. Use as internal standard. Possible use in other biological systems. See similar products
The product is subject to the following: Abcam Restricted Use Statement
Apexbio Technology LLC TH588 1609960-31-7 10mM (in 1mL DMSO)
TH588 (CAS 1609960-31-7) is a selective small-molecule inhibitor of MTH1 (MutT Homolog 1) a purine nucleoside triphosphatase that prevents incorporation of oxidized nucleotides into DNA TH588 inhibits MTH1 with an IC50 of 5 nM and has been shown to increase DNA 8-oxodG levels in cancer cells leading to DNA damage and activation of ATM-p53-mediated cell death and repair pathways In cellular models such as U2OS and other cancer cell lines TH588 preferentially induces cytotoxicity in malignant cells with reduced effects on primary or immortalized non-cancerous cells In BRAF V600E mutant melanoma xenografts TH588 treatment attenuates tumor growth supporting its use in research on oxidative stress DNA damage and novel anticancer strategies
Cayman Chemical ANTIBODY TEMPOn 10g
The 4-oxo derivative of TEMPO; possible uses as a spin trap, in hydrogen transfer experiments, and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy
Medchemexpress LLC HY-16562A 200mg , Irinotecan (hydrochloride) CAS:100286-90-6 Purity:>98%
HY-16562A 200mg Irinotecan (hydrochloride) CAS: 100286-90-6 Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Denfivontinib | 1457983-28-6 | MFCD28167815 | 98.0% | 521.41 g/mol | C25H25BrN6O2 | 50MG
Denfivontinib (G-749) is a potent, orally active ATP-competitive inhibitor of FMS-like tyrosine kinase 3 (FLT3) developed for research applications, including studies of drug resistance in acute myeloid leukemia (AML). It inhibits wild-type and mutant FLT3 at sub-nanomolar concentrations and is supplied as a solid research compound.
- Potent FLT3 inhibition: IC50 0.4 nM (wild type), 0.6 nM (D835Y)
- CAS number: 1457983-28-6
- Chemical formula: C25H25BrN6O2
- Molecular weight: 521.41 g/mol
- Purity: 98.0%
- Physical form: white to off-white solid; hydrochloride salt available
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years)
- Intended use: research tool compound for AML and kinase studies